The Bandim Health Project, Guinea Bissau – Enreca Health

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The Bandim Health Project, Guinea Bissau

Institutional background in brief: The Bandim Health Project was initiated in 1978 with the aim of improving child survival in Guinea Bissau. The project is currently based on collaboration between the Ministry of Health, Guinea Bissau, Statens Serum Institut Denmark, and researchers affiliated to University of Copenhagen, and University of Aarhus, Denmark.   

Research focus

The Bandim Health Project has in the past 25 years expanded its focus to include

Population based health research, primarily focusing on child and maternal health, including studies of the epidemiology or treatment of measles, lower respiratory infection, RSV, diarrhoea, malaria, TB and HIV.

The Project has also worked extensively with the effects of health strategies promoted by the international community, including vaccination strategies, breastfeeding promotion, diarrhoea control, vitamin A supplementation and micronutrient supplementation during pregnancy.

Under these headlines, the main research components include:
Measles: epidemiology, mortality and vaccination
Diarrhoea and its etiology
Respiratory infections and malaria
Nutrition, including micronutrients and breastfeeding
The health system: epidemiology and mortality
Unspecific effects of routine vaccinations (child mortality)
Tuberculosis, HIV, and immunodeficiency
Population growth and its health consequences
Humanitarian aid and the consequences of war

Researchers’ profiles

The academic staff includes 15 Guinean physicians and 2 expatriate (a physician and an anthropologist). The project also includes close to 100 local supervisors, field workers, technicians and other staff. Currently, 14 Ph.D. students are affiliated to the project.

Research collaboration

The Bandim Health project collaborates with the Medical Research Council Laboratories in the Gambia, and the French IRD (Institute of Development Research), Senegal.
Aarhus University, Denmark
Leiden University, Holland, IRD, Montpellier, France

Involvement in capacity development (examples)

During the course of this project, 25 doctor or Ph.D. degrees have been concluded. Also eight Guinean/Senegalese Masters of Science have been completed.
The researchers in the Bandim group have taken part in the formation of the Graduate School of International Health.

Consultancies

No

Peer reviewed publications

Gustafson P, Gomes VF, Vieira CS, Seng R, Samb B, Nauclér A, Aaby P. Tuberculosis mortality during a civil war in Guinea-Bissau. JAMA 2001;286:599-603

Benn CS, Bale C, Sommerfelt H, Friis H, Aaby P. Vitamin A supplementation and childhood mortality: Amplification of the non-specific effects of vaccines? Int J Epidemiol 2003:32: 822-8

Garly ML, Martins CL, Balé C, Baldé MA, Hedegaard KL, Gustafson P, Lisse IM, Whittle HC, Aaby P. BCG scar and positive tuberculin reaction associated with reduced child mortality: A non-specific beneficial effect of BCG? Vaccine 2003;21:2782-90

Holmgren B, da Silva Z, Larsen O, Vastrup P, Andersson S, Aaby P. Dual infections of HIV-1, HIV-2, and HTLV-I are more common in older women than men in Guinea-Bissau. AIDS 2003;17:241-53

Steinsland H, Valentiner-Branth P, Gjessing HK, Aaby P, Mølbak K, Sommerfelt H. Protection from natural infections with enterotoxigenic Esherichia coli: longitudinal study. Lancet 2003; 362: 286-91.

Aaby P, Jensen H, Samb B, Cisse B, Sodeman M, Jakobsen M, Poulsen A, Rodrigues A, Lisse IM, Simondon F, Whittle H. Differences in female-male mortality after high-titre measles vaccine and association with subsequent vaccination with diphtheria-tetanus-pertussis and inactivated poliovirus:  reanalysis of  West African studies.  Lancet 2003;361: 2183-88

Aaby P, Jensen H, Rodrigues A, Garly ML, Benn CS, Lisse IM, Simondon F. Divergent female-male mortality ratios associated with different routine vaccinations among female-male twin pairs. Int J Epidemiol 2004;33:367-73

Aaby P, Jensen H, Gomes J, Fernandes M, Lisse IM. The introduction of diphtheria-tetanus-pertussis vaccine and child mortality in rural Guinea-Bissau: An observational study. Int J Epidemiol 2004,33:374-80

Benn CS, Melbye M, Wohlfahrt J, Björkstén B, Aaby P. Cohort study of sibling effect, infectious diseases, and risk of atopic dermatitis during the first 18 months of life. BMJ 2004;1223

Garly ML, Jensen H, Martins CL, Balé C, Balde MA, Lisse IM, Aaby P Hepatitis-B vaccination may be associated with an increased female mortality in Guinea-Bissau: An observational study. Pediatr Infect Dis J (in press)

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